Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.

Autor: Ulugut H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Bertoux M; Lille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France., Younes K; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Stanford Neuroscience Health Center, Department of Neurology, Stanford University, Palo Alto, California, USA., Montembeault M; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Department of Psychiatry, Douglas Mental Health University Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada., Fumagalli GG; Department of Neurology, University of Milan, Milan, Italy.; Università degli Studi di Trento | UNITN·CIMEC - Center for Mind/Brain Sciences, Mattarello, Trentino, Italy., Samanci B; Department of Neurology, Istanbul University, Fatih, Istanbul, Turkey., Illán-Gala I; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Kuchcinski G; Lille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France., Leroy M; Lille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France., Thompson JC; Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Salford, Manchester, UK., Kobylecki C; Department of Neurology, Manchester Centre for Clinical Neurosciences NHS Foundation Trust, Salford, UK.; Division of Neuroscience, University of Manchester, Salford, Manchester, UK., Santillo AF; Clinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden., Englund E; Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden., Waldö ML; Division of Clinical Sciences Helsingborg, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Riedl L; School of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany., Van den Stock J; Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium., Vandenbulcke M; Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium., Vandenberghe R; Department of Neurology, University Hospital Leuven, Leuven, Belgium., Laforce R Jr; Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, Laval University, Quebec City, Canada., Ducharme S; Department of Psychiatry, Douglas Mental Health University Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada., Pressman PS; Anschutz Medical Campus, Behavioral Neurology Section, Department of Neurology, University of Colorado, Aurora, Colorado, USA., Caramelli P; Behavioral and Cognitive Neurology Unit, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Souza LC; Behavioral and Cognitive Neurology Unit, Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Takada LT; Cognitive and Behavioral Unit, Hospital das Clinicas, Department of Neurology, University of São Paulo Medical School, Pacaembu, São Paulo, Brazil., Gurvit H; Department of Neurology, Istanbul University, Fatih, Istanbul, Turkey., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden., Diehl-Schmid J; School of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.; Kbo-Inn-Salzach-Klinikum, Clinical Center for Psychiatry, Psychotherapy, Psychosomatic Medicine, Geriatrics and Neurology, Wasserburg/Inn, Germany., Galimberti D; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Pasquier F; Lille Neuroscience & Cognition U1172, Univ. Lille, Inserm, CHU Lille, LiCEND & Labex DistALZ, Lille, France., Miller BL; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands., Ossenkoppele R; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.; Alzheimer Center Amsterdam, Department of Radiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands., Barkhof F; Alzheimer Center Amsterdam, Department of Radiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.; UCL Institutes of Neurology and Healthcare Engineering, University College London, London, UK., Fox NC; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Sturm VE; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Miyagawa T; Department of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA., Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, Rochester, Minnesota, USA., Boeve B; Department of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA., Rohrer JD; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Dyslexia Center, University of California San Francisco, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Josephs KA; Department of Neurology, Mayo Clinic, Rochester, Rochester, Minnesota, USA., Snowden J; Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Salford, Manchester, UK., Warren JD; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Rankin KP; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5647-5661. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1002/alz.14076
Abstrakt: Introduction: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.
Methods: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.
Results: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.
Discussion: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.
Highlights: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: