Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation.

Autor: Letourneau J; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Neubert BC; Program in Computational Biology and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Dayal D; School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Carrion VM; Duke Office of Clinical Research, Duke University, Durham, NC, USA., Durand HK; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Dallow EP; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Jiang S; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Kirtley M; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Ginsburg GS; Duke Center for Applied Genomics and Precision Medicine, Duke University Health System, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Doraiswamy PM; Duke Center for Applied Genomics and Precision Medicine, Duke University Health System, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.; Duke Microbiome Center, Duke University School of Medicine, Durham, NC, USA., David LA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.; Program in Computational Biology and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.; Duke Microbiome Center, Duke University School of Medicine, Durham, NC, USA.
Jazyk: angličtina
Zdroj: International journal of food sciences and nutrition [Int J Food Sci Nutr] 2024 Sep; Vol. 75 (6), pp. 571-581. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1080/09637486.2024.2372590
Abstrakt: Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised side effects in an exploratory analysis of a randomised trial in healthy adults ( n  = 40) who consumed 18 g/day inulin or placebo. We found that individuals weighing more or habitually consuming higher fibre exhibited the best tolerance. Furthermore, we identified associations between gut microbiome composition and host tolerance. Specifically, higher levels of Christensenellaceae R-7 group were associated with gastrointestinal discomfort, and a machine-learning-based approach successfully predicted high levels of flatulence, with [Ruminococcus] torques group and ( Oscillospiraceae ) UCG-002 sp. identified as key predictive taxa. These data reveal trends that can help guide personalised recommendations for initial inulin dosage. Our results support prior ecological findings indicating that fibre supplementation has the greatest impact on individuals whose baseline fibre intake is lowest.
Databáze: MEDLINE