Diacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1/ PON 1.

Autor: Shah MZUH; Laboratory of Endocrinology, Department of Bioscience, Barkatullah University, Madhya Predesh, Bhopal, 462026, India.; Department of obstetrics and Gynecology, Centre for Reproductive Medicine, the Fourth Affiliated Hospital of school of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China., Shrivastava VK; Laboratory of Endocrinology, Department of Bioscience, Barkatullah University, Madhya Predesh, Bhopal, 462026, India., Muzamil S; Molecular Biology Laboratory, Faculty of Veterinary Sciences and Animal Husbandary, SKAUST-K, Srinagar, India., Olaniyi KS; Department of Physiology, College of Medicine and Health Sciences, Cardio/Endo-metabolic and Microbiome Research Unit, Afe Babalola University, Ado-Ekiti, 360101, Nigeria. olaniyisk@abuad.edu.ng.
Jazyk: angličtina
Zdroj: BMC endocrine disorders [BMC Endocr Disord] 2024 Jul 10; Vol. 24 (1), pp. 109. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1186/s12902-024-01639-9
Abstrakt: Background: This study aimed to explore the impact of Diacerein (DIC) on endocrine and cardio-metabolic changes in polycystic ovarian syndrome (PCOS) mouse model.
Methods: A total of 18 adult female mice (Parkes strain), aged 4-5 weeks, were randomly assigned to three groups, each comprising 6 animals, as follows: Group I (control), received normal diet and normal saline as vehicle for 51 days; Group II received Letrozole (LET; 6 mg/kg bw) for 21 days to induce PCOS; Group III received LET, followed by daily oral gavage administration of DIC (35 mg/kg bw) for 30 days.
Results: This study indicates that treatment with LET resulted in PCOS with characteristics such as polycystic ovaries, elevated testosterone, weight gain, visceral adiposity, high levels of insulin as well as fasting blood glucose in addition to insulin resistance, improper handling of ovarian lipids, atherogenic dyslipidemia, impaired Na + /K + -ATPase activity and serum, cardiac, and ovarian oxidative stress. Serum/ovarian adiponectin levels were lowered in LET-treated mice. In mice treated with LET, we also discovered a reduction in cardiac and serum paraoxonase 1 (PON1). Interestingly, DIC restored ovarian andcardio-metabolic abnormalities in LET-induced PCOS mice. DIC prevented the endocrine and cardio-metabolic changes brought on by letrozole-induced PCOS in mice.
Conclusion: The ameliorative effects of DIC on letrozole-induced PCOS with concurrent oxidative stress, abdominal fat deposition, cardiac and ovarian substrate mishandling, glucometabolic dysfunction, and adiponectin/PON1 activation support the idea that DIC perhaps, restore compromised endocrine and cardio-metabolic regulators in PCOS.
(© 2024. The Author(s).)
Databáze: MEDLINE
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