Characterizing drug-induced epidermal necrolysis in a pediatric cohort.

Autor: Brown AB; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Park AJ; Metropolis Dermatology, Los Angeles, California, USA., Agim NG; Forefront Dermatology, Dallas, Texas, USA.; Lake Granbury Medical Center Dermatology Residency, Bare Dermatology, Granbury, Texas, USA., Gordon KA; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2024 Nov-Dec; Vol. 41 (6), pp. 1127-1130. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1111/pde.15693
Abstrakt: This study aims to characterize the timeline and clinical features of onset, progression, and management of drug-induced epidermal necrolysis in pediatric patients. Sixteen pediatric patients were retrospectively identified and selected if under age 18 years at admission with one identified culprit drug exposure. Culprit drugs were antiepileptics (12/16, 75%) and antibiotics (4/16, 25%). Notably, anti-epileptic drugs (AED) had delayed onset and reported dose escalations that precipitated symptom onset; thus, patients prescribed AED with or without planned dose escalations should be monitored for prodromal symptoms longer than the typical onset window.
(© 2024 The Author(s). Pediatric Dermatology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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