Dissecting the vascular-cognitive nexus: energetic vs. conventional hemodynamic parameters.

Autor: Cheng HM; Division of Faculty Development, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. hmcheng@vghtpe.gov.tw.; Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. hmcheng@vghtpe.gov.tw.; Institute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan, ROC. hmcheng@vghtpe.gov.tw., Wang JJ; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan, ROC., Chuang SY; Institute of Population Health Science, National Health Research Institute, Miaoli, Taiwan, ROC., Lin CH; Institute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan, ROC., Mitchell GF; Cardiovascular Engineering, Inc., Norwood, MA, USA., Huang CJ; Division of Faculty Development, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Wang PN; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC., Chung CP; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC., Chen LK; Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Pan WH; Institute of Population Health Science, National Health Research Institute, Miaoli, Taiwan, ROC.; Institute of Biomedical Science, Academia Sinica, Taipei, ROC., Peng LN; Aging and Health Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. lining.peng@gmail.com.; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. lining.peng@gmail.com., Chen CH; Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. chchen3@nycu.edu.tw.; Institute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan, ROC. chchen3@nycu.edu.tw.
Jazyk: angličtina
Zdroj: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Sep; Vol. 47 (9), pp. 2262-2274. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1038/s41440-024-01735-2
Abstrakt: Blood pressure or flow measurements have been associated with vascular health and cognitive function. We proposed that energetic hemodynamic parameters may provide a more nuanced understanding and stronger correlation with cognitive function, in comparisons with conventional aortic and carotid pressure and flow parameters. The study comprised 1858 participants, in whom we assessed cognitive function via MoCA method, and measured central aortic and carotid pressure and flow waveforms. In addition to various pressure and flow parameters, we calculated energetic hemodynamic parameters through integration of pressure multiplying flow with respect to time. Energetic hemodynamic parameters, particularly aortic and carotid mean and pulsatile energy and pulsatility index (PI), were significantly associated with MoCA score more than any aortic and carotid pressure and flow parameters, after adjusting for age, sex, education, depression score, heart rate, BMI, HDL-cholesterol, and glucose levels. MoCA exhibited a strong positive relationship with carotid mean energy (standardized beta = 0.053, P = 0.0253) and a negative relationship with carotid energy PI (standardized beta = -0.093, P = 0.0002), exceeding the association with all traditional pressure- or flow-based parameters. Aortic pressure reflection coefficient at the aorto-carotid junction was positively correlated with mean carotid energy and negatively correlated with PI. Aortic characteristic impedance positively correlated with carotid energy PI but not mean energy. Our research indicates that energetic hemodynamic parameters, particularly carotid mean energy and carotid energy PI, have a stronger association with MoCA scores than traditional pressure- or flow-based metrics. This correlation with cognitive function is notably influenced by the properties of the aorto-carotid interface.
(© 2024. The Author(s).)
Databáze: MEDLINE
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