Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study.

Autor: Bålsrud P; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Ulven SM; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Ottestad I; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.; Clinical Nutrition, Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway., Retterstøl K; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.; The Lipid Clinic, Oslo University Hospital, Oslo, Norway., Schwab U; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Wellbeing Services County of North Savo, Kuopio, Finland., Holven KB; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. k.b.holven@medisin.uio.no.; National Advisory Unit On Familial Hypercholesterolemia, Oslo University Hospital, Oslo, Norway. k.b.holven@medisin.uio.no.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Dec; Vol. 46 (6), pp. 5629-5641. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1007/s11357-024-01279-w
Abstrakt: Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty Index (FI) definition to (1) investigate the association between levels of inflammatory markers (baseline) and change in FI score after 8 years of follow-up and (2) investigate the longitudinal associations between inflammatory markers, body composition, and frailty. Home-dwelling elderly (≥ 70 years) were invited to participate in the study and re-invited to a follow-up visit 8 years later. This study includes a total of 133 participants. The inflammatory markers included were high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and glycoprotein acetyls (Gp-acetyls). We used the body composition markers fat mass, fat-free mass, and waist circumference. The FI score consisted of 38 variables. Additional clinical assessments such as blood pressure and body mass index (BMI), as well as information about daily medications, were collected at both visits. Linear regression model and Spearman's rank correlation were used to investigate associations. We showed that the FI score increased after 8 years, and participants with higher hs-CRP levels at baseline had the largest change in the FI score. Changes in fat mass were significantly correlated with changes in hs-CRP and IL-6, and changes in waist circumference were significantly correlated with changes in TNF-α. The use of drugs increased during the 8 years of follow-up, which may have attenuated the associations between inflammation and frailty. However, elevated concentrations of hs-CRP in the elderly may be associated with an increased risk of frailty in subsequent years.
(© 2024. The Author(s).)
Databáze: MEDLINE
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