Development of a new magnetic solid-phase extraction method prior to HPLC determination of naproxen in pharmaceutical products and water samples.

Autor: Karataş A; Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Analytical Chemistry, Sivas 58140, Turkey., Oymak T; Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Analytical Chemistry, Sivas 58140, Turkey. Electronic address: tulayoymak@cumhuriyet.edu.tr., Çeli K A; Ankara Yildirim Beyazit University, Faculty of Engineering and Natural Sciences, Department of Chemical Engineering, Ankara, Turkey. Electronic address: acelik@aybu.edu.tr.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Oct 15; Vol. 249, pp. 116336. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1016/j.jpba.2024.116336
Abstrakt: In this study, a new magnetic solid phase extraction based on magnetic composite modified with biochar obtained from pumpkin peel was developed for the enrichment and extraction of Naproxen in lake water, tablet and urine samples. The effects of main parameters such as pH, extraction time, amount of adsorbent and sample volume, which affect magnetic solid phase extraction, were investigated. Under optimal conditions, intraday and interday precision values for naproxen were below 5.9, with accuracy (relative error) better than 7.0 %. The detection limit and preliminary concentration factor were 12 ng/mL and 10, respectively. The method proposed here can be used for routine analysis of naproxen in lake water, urine and tablets.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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