| Autor: |
Iwata T; Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasugako-en, Kasuga, Fukuoka 816-8580, Japan., Hatae K; Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasugako-en, Kasuga, Fukuoka 816-8580, Japan., Shindo M; Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasugako-en, Kasuga, Fukuoka 816-8580, Japan. |
| Abstrakt: |
Herein, we report an efficient and practical method for synthesizing α,α-dibromo esters, which are the precursors of ynolates, through the dibromination of aldehydes followed by oxidative esterification using iodine. Our method was successfully employed in a large-scale synthesis to yield more than 30 g of dibromo esters. These two steps can be performed in a one-pot manner, which makes the method adaptable even for aldehydes having low boiling points. |
