Pharmabiotic/phytobiotic formulas approach and their intravaginal effect on different parameters.

Autor: Miranda MH; Centro de Referencia para Lactobacilos, CONICET. Chacabuco 145, San Miguel de Tucumán, CP4000, Tucumán, Argentina., Nader-Macías MEF; Centro de Referencia para Lactobacilos, CONICET. Chacabuco 145, San Miguel de Tucumán, CP4000, Tucumán, Argentina. fnader@cerela.org.ar.
Jazyk: angličtina
Zdroj: Veterinary research communications [Vet Res Commun] 2024 Oct; Vol. 48 (5), pp. 3019-3033. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1007/s11259-024-10450-9
Abstrakt: Postpartum reproductive infections in cows generate significant economic losses. The use of lactic acid bacteria in animal health is an alternative tool to avoid antibiotic therapy in the prevention/treatment of bovine reproductive infections. In previous studies, 6 lactic bacteria from bovine mammary glands and vagina with beneficial, safe and technological characteristics were selected, and included in probiotic/phytobiotic formulas (combined with Malva and Lapacho extracts). In this work, probiotic and phytobiotic formulations were designed and their long-term viability determined. They were administered intravaginally to 30 females pregnant bovine pre and postpartum. The modification of the native microbiota and permanence/colonization of cultivable bacteria was evaluated, and also the safety of the designed products through the application of nutritional, clinical, hematological and biochemical parameters. The microorganisms maintained their viability up to 9 months at refrigeration temperature. The number of cultivable bacteria showed different pattern: total aerobic mesophylls increased slightly in all experimental groups, while Enterobacteriaceae increased after delivery, except in beneficial acid lactic bacteria + vegetable extract cows. Control and vegetable extract females showed the highest numbers of Enterobacteriaceae at the end of the trial (30 days postpartum). The number of lactic acid bacteria increased significantly in all the groups between 15 days pre and postpartum. The different parameters evaluated demonstrate the safety and harmlessness of the designed formulas, without producing local and systemic adverse effects in the cows.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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