New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection.

Autor: Sikiric P; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia. sikiric@mef.hr., Sever M; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia., Krezic I; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Vranes H; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Kalogjera L; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Smoday IM; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Vukovic V; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Oroz K; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Coric L; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Skoro M; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Diagnostic and Interventional Radiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia., Kavelj I; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Diagnostic and Interventional Radiology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia., Zubcic S; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Sikiric S; Department of Pathology, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia., Beketic Oreskovic L; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Oreskovic I; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Blagaic V; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Brcic K; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Strbe S; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Staresinic M; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia., Boban Blagaic A; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia., Skrtic A; Department of Pathology, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia., Seiwerth S; Department of Pathology, School of Medicine, University of Zagreb, 10000, Zagreb, Croatia.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2024 Oct; Vol. 32 (5), pp. 3119-3161. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1007/s10787-024-01499-8
Abstrakt: Since the early 1990s, when Robert's and Szabo's cytoprotection concept had already been more than one decade old, but still not implemented in therapy, we suggest the stable gastric pentadecapeptide BPC 157 as the most relevant mediator of the cytoprotection concept. Consequently, it can translate stomach and gastrointestinal mucosal maintenance, epithelium, and endothelium cell protection to the therapy of other tissue healing (organoprotection), easily applicable, as native and stable in human gastric juice for more than 24 h. These overwhelm current clinical evidence (i.e., ulcerative colitis, phase II, no side effects, and no lethal dose (LD1) in toxicology studies), as BPC 157 therapy effectively combined various tissue healing and lesions counteraction. BPC 157 cytoprotection relevance and vascular recovery, activation of collateral pathways, membrane stabilizer, eye therapy, wound healing capability, brain-gut and gut-brain functioning, tumor cachexia counteraction, muscle, tendon, ligament, and bone disturbances counteraction, and the heart disturbances, myocardial infarction, heart failure, pulmonary hypertension, arrhythmias, and thrombosis counteraction appeared in the recent reviews. Here, as concept resolution, we review the counteraction of advanced Virchow triad circumstances by activation of the collateral rescuing pathways, depending on injury, activated azygos vein direct blood flow delivery, to counteract occlusion/occlusion-like syndromes starting with the context of alcohol-stomach lesions. Counteraction of major vessel failure (congested inferior caval vein and superior mesenteric vein, collapsed azygos vein, collapsed abdominal aorta) includes counteraction of the brain (intracerebral and intraventricular hemorrhage), heart (congestion, severe arrhythmias), lung (hemorrhage), and congestion and lesions in the liver, kidney, and gastrointestinal tract, intracranial (superior sagittal sinus), portal and caval hypertension, aortal hypotension, and thrombosis, peripherally and centrally.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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