Sex/gender differences in spontaneous reports to a French Addictovigilance centre.

Autor: Peyriére H; Addictovigilance Center, University Hospital, Montpellier, France. h-peyriere@chu-montpellier.fr.; INSERM U 1058, Pathogenesis and Control of Chronic Infections (PCCI), Montpellier, France. h-peyriere@chu-montpellier.fr.; Service de Pharmacologie Médicale et Toxicologie, Hôpital Lapeyronie, 370 avenue du Doyen Gaston Giraud, Montpellier Cedex 5, 34925, France. h-peyriere@chu-montpellier.fr., Dampierre A; Addictovigilance Center, University Hospital, Montpellier, France., Vallo R; INSERM U 1058, Pathogenesis and Control of Chronic Infections (PCCI), Montpellier, France., Lestienne M; Addictovigilance Center, University Hospital, Montpellier, France., Eiden C; Addictovigilance Center, University Hospital, Montpellier, France., Donnadieu H; INSERM U 1058, Pathogenesis and Control of Chronic Infections (PCCI), Montpellier, France.; Addictions Department, University Hospital, Montpellier, France.
Jazyk: angličtina
Zdroj: Archives of women's mental health [Arch Womens Ment Health] 2024 Jul 09. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1007/s00737-024-01486-6
Abstrakt: To specify psychoactive substances and related complications observed in spontaneous reports (SRs) in women versus men, we assessed SRs on substance-linked acute toxicity sent to a French Addictovigilance centre. Over the period 2021-2022, 880 SRs were analysed (33.4% concerned women). Severe complications concerned more men than women (70.3% versus 59.5%; p = 0.0014). In women, the main implicated substances were psychoactive medications (opioids, benzodiazepines). The most frequently reported complication was suicidal behaviour (14.6% versus 7.8%, p = 0.002). In men, SRs concerned mainly illicit substances (cocaine, amphetamines) or misuse of opioid maintenance therapy or nitrous oxide. The main complications in men were infections (12.97% versus 5.4%, p = 0.0006) and neurological troubles (37.6% versus 23.5%, p < 0.0001).Our data highlight sex/gender disparities in substance use and complications, in agreement with recent literature and French national Addictovigilance data.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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