Generation and repair of thymic epithelial cells.
| Autor: | Anderson G; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK., Cosway EJ; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK., James KD; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK., Ohigashi I; Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, Japan., Takahama Y; Thymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of experimental medicine [J Exp Med] 2024 Oct 07; Vol. 221 (10). Date of Electronic Publication: 2024 Jul 09. |
| DOI: | 10.1084/jem.20230894 |
| Abstrakt: | In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function. (© 2024 Anderson et al.) |
| Databáze: | MEDLINE |
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