Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma.

Autor: Pittar A; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Buckley EJ; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Boyle ST; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia., Ibbetson SJ; Division of Surgical Pathology, SA Pathology, Adelaide, Australia., Samuel MS; Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Basil Hetzel Institute for Translational Health Research, Woodville South, Adelaide, Australia.
Jazyk: angličtina
Zdroj: Cytoskeleton (Hoboken, N.J.) [Cytoskeleton (Hoboken)] 2024 Dec; Vol. 81 (12), pp. 864-871. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1002/cm.21894
Abstrakt: A key characteristic of cancer cells is their ability to induce changes in their microenvironment that render it permissive to tumor growth, invasion and metastasis. Indeed, these changes are required for tumor progression. Consequently, the tumor microenvironment is emerging as a key source of new targets against cancer, with novel therapies aimed at reversing tumor-promoting changes, reinstating a tumor-hostile microenvironment and suppressing disease progression. RHO-ROCK signaling, and consequent tension within the cellular actomyosin cytoskeleton, regulates a paracrine signaling cascade that establishes a tumor-promoting microenvironment. Here, we show that consistent with our observations in breast cancer, enhanced ROCK activity and consequent production of CRELD2 is associated with the recruitment and tumor-promoting polarization of cancer-associated fibroblasts in cutaneous squamous cell carcinoma. Our observations provide support for the notion that the role of RHO-ROCK signaling in establishing a tumor-promoting microenvironment may be conserved across patients and potentially also different cancer types.
(© 2024 The Author(s). Cytoskeleton published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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