SMARCB1/INI1-deficient undifferentiated tumour of the thorax: a case report and review of the literature.

Autor: Zagni M; Postgraduate School of Pathology, University of Milan, Milan, Italy., Marando A; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Negrelli M; Postgraduate School of Pathology, University of Milan, Milan, Italy., Lauricella C; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Motta V; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Paglino G; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Veronese S; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Valtorta E; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Bonoldi E; Department of Surgical Pathology, Niguarda Hospital, Milano, Italy., Pelosi G; Postgraduate School of Pathology, University of Milan, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; Inter-Hospital Pathology Division, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Milan, Italy.
Jazyk: angličtina
Zdroj: Pathologica [Pathologica] 2024 Jun; Vol. 116 (3), pp. 163-169.
DOI: 10.32074/1591-951X-955
Abstrakt: The 5th WHO classification of thoracic tumours includes thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-UT) among the "other epithelial tumours of the lung" chapter. Herein, we present a case of undifferentiated thoracic neoplasm with retention of SMARCA4 expression, lack of NUT fusion protein and loss of SMARCB1/INI1 expression. After presenting the clinical and pathological features of the tumour, we carried out a review of the literature on the same topic. Albeit very rare, we believe this entity should be included in the heterogeneous group of undifferentiated neoplasms of the thorax.
(Copyright © 2024 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.)
Databáze: MEDLINE
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