Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report.

Autor:	Verdelli A; Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member., Massi D; Section of Pathology., Maio V; Section of Pathology., Cavazza G; Section of Dermatology, Department of Health Sciences, University of Florence, Italy., Corrà A; Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member., Mariotti EB; Section of Dermatology, Department of Health Sciences, University of Florence, Italy., Quintarelli L; Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member., di Calabria VR; Section of Dermatology, Department of Health Sciences, University of Florence, Italy., Aimo C; Section of Dermatology, Department of Health Sciences, University of Florence, Italy., Antiga E; Section of Dermatology, Department of Health Sciences, University of Florence, Italy., Caproni M; Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member.; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Jazyk:	angličtina
Zdroj:	Dermatology reports [Dermatol Reports] 2023 Oct 17; Vol. 16 (2), pp. 9771. Date of Electronic Publication: 2023 Oct 17 (Print Publication: 2024).
DOI:	10.4081/dr.2023.9771
Abstrakt:	A subtype of cutaneous lupus erythematosus known as lupus erythematosus tumidus (LET) is characterized by sun-exposed areas that typically display urticaria-like papules and plaques. For LET, systemic therapy with antimalarials - particularly hydroxychloroquine (HCQ) - is the first line of treatment. Even though the safety profile of these medications appears to be high, there have been very few reports of side effects in the literature, including hemolytic anemia, retinal toxicity, maculopapular rash, gastrointestinal disturbance, and blue-gray discoloration of the skin or mucous membranes. Here, we report a unique instance of a 46-year-old LET smoker who, following HCQ treatment, developed a generalized myopathy. Competing Interests: Conflict of interest: the authors declare no potential conflict of interest. (Copyright © 2024, the Author(s).)
Databáze:	MEDLINE
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