Perineural Invasion of Cranial Nerves in Cutaneous Squamous Cell Carcinoma: Unraveling Its Complexities, Diagnostic Challenges, and Multifaceted Treatment Approaches.

Autor:	Zárate-García JP; Department of Neurosurgery, American British Cowdray (ABC) Medical Center, Mexico City, MEX., Ortega-Porcayo LA; Department of Neurosurgery, American British Cowdray (ABC) Medical Center, Mexico City, MEX., Tejada-Pineda MF; School of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, MEX., Moscardini-Martelli J; Department of Neurosurgery, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MEX., Romano-Feinholz S; Department of Neurosurgery, American British Cowdray (ABC) Medical Center, Mexico City, MEX., Ponce-Gómez JA; Department of Neurosurgery, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MEX., Osuna-Zazueta MA; Department of Neuroanesthesiology, American British Cowdray (ABC) Medical Center, Mexico City, MEX., Zárate-García AN; School of Medicine and Health Sciences, Facultad Mexicana de Medicina Universidad La Salle, Mexico City, MEX., Guillén-Camacho ME; Department of Neuroanesthesiology, American British Cowdray (ABC) Medical Center, Mexico City, MEX., Jiménez SM; Radiosurgery Unit, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Mexico City, MEX.; Department of Neurosurgery-Radiosurgery, American British Cowdray (ABC) Medical Center, Mexico City, MEX.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 06; Vol. 16 (6), pp. e61854. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).
DOI:	10.7759/cureus.61854
Abstrakt:	Cutaneous squamous cell carcinoma is the second most common neoplasm among non-melanoma skin cancers. When associated with perineural invasion of the cranial nerves, with clinical features often observed in trigeminal and facial nerves due to their cutaneous extension, it may lead to a worse prognosis. This paper introduces a rare case of an 81-year-old male, with a history of a moderately differentiated invasive carcinoma of the left frontal region with perineural invasion on the left trigeminal cranial nerve. The case underscores the aggressive nature of the intraneural infiltration by squamous cell carcinoma and the challenges in managing such advanced malignancies. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Zárate-García et al.)
Databáze:	MEDLINE
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