Possible involvement of sialidase and sialyltransferase activities in a stage-dependent recycling of sialic acid in some organs of type 1 and type 2 diabetic rats.

Autor:	Erhabor OG; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria., Obochi P; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria., Isah MB; Department of Biochemistry, Umaru Musa Yar'adua University, Katsina, Nigeria., Usman MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria., Umar IA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria., Simelane MBC; Department of Biochemistry, University of Johannesburg, Johannesburg, South Africa., Shuaibu MN; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria., Islam MS; School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa., Ibrahim MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jun 24; Vol. 15, pp. 1289653. Date of Electronic Publication: 2024 Jun 24 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1289653
Abstrakt:	Background: Type 1 (T1D) and type 2 (T2D) diabetes lead to an aberrant metabolism of sialoglycoconjugates and elevated free serum sialic acid (FSSA) level. The present study evaluated sialidase and sialyltranferase activities in serum and some organs relevant to diabetes at early and late stages of T1D and T2D. Methods: Sialic acid level with sialidase and sialyltransferase activities were monitored in the serum, liver, pancreas, skeletal muscle and kidney of diabetic animals at early and late stages of the diseases. Results: The FSSA and activity of sialidase in the serum were significantly increased at late stage of both T1D and T2D while sialic acid level in the liver was significantly decreased in the early and late stages of T1D and T2D, respectively. Furthermore, the activity of sialidase was significantly elevated in most of the diabetes-relevant organs while the activity of sialyltransferase remained largely unchanged. A multiple regression analysis revealed the contribution of the liver to the FSSA while pancreas and kidney contributed to the activity of sialidase in the serum. Conclusions: We concluded that the release of hepatic sialic acid in addition to pancreatic and renal sialidase might (in)directly contribute to the increased FSSA during both types of diabetes mellitus. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Erhabor, Obochi, Isah, Usman, Umar, Simelane, Shuaibu, Islam and Ibrahim.)
Databáze:	MEDLINE
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