Brain clocks capture diversity and disparity in aging and dementia.

Autor:	Moguilner S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Baez S; Universidad de los Andes, Bogota, Colombia.; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland., Hernandez H; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Migeot J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Legaz A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Gonzalez-Gomez R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Farina FR; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; The University of California Santa Barbara (UCSB), California, USA., Prado P; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago de Chile, Chile., Cuadros J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Grupo de Bioingeniería, Decanato de Investigación, Universidad Nacional Experimental del Táchira, San Cristóbal 5001, Venezuela.; Pontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia., Tagliazucchi E; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; University of Buenos Aires, Argentina., Altschuler F; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Maito MA; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Godoy ME; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Cruzat J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valdes-Sosa PA; The Clinical Hospital of Chengdu Brain Sciences, University of Electronic Sciences.; Technology of China, Chengdu, China; Cuban Neuroscience Center, La Habana, Cuba., Lopera F; Grupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia., Ochoa-Gómez JF; Grupo de Neurociencias de Antioquia (GNA) University of Antioquia, Medellín, Colombia., Hernandez AG; Department of Psychology, Master program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Neiva - Huila, Colombia., Bonilla-Santos J; Department of Psychology, Universidad Cooperativa de Colombia., Gonzalez-Montealegre RA; Neurocognition and Psychophysiology Laboratory, Universidad Surcolombiana, Neiva - Huila, Colombia., Anghinah R; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., d'Almeida Manfrinati LE; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., Fittipaldi S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Universidad de los Andes, Bogota, Colombia., Medel V; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Olivares D; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology program-Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile.; Centro de Neuropsicología Clínica (CNC), Santiago, Chile., Yener GG; Faculty of Medicine, Izmir University of Economics, 35330, Izmir, Turkey.; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, Izmir, Turkey.; Izmir Biomedicine and Genome Center, Izmir, Turkey., Escudero J; School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Scotland, UK., Babiloni C; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.; Hospital San Raffaele Cassino, Cassino, (FR), Italy., Whelan R; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; School of Psychology, Trinity College Dublin, Dublin 2, Ireland., Güntekin B; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey.; Department of Biophysics, School of Medicine, Istanbul Medipol University., Yırıkoğulları H; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey., Santamaria-Garcia H; Pontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., Lucas AF; Departamento de Medicina Legal, Psiquiatría y Patología, Facultad de Medicina, Universidad Complutense de Madrid., Huepe D; Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibáñez., Di Caterina G; Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK., Soto-Añari M; Universidad Católica San Pablo, Arequipa, Peru., Birba A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Sainz-Ballesteros A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Coronel-Oliveros C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Chile., Yigezu A; Trinity College Dublin, The University of Dublin, Dublin, Ireland., Herrera E; Departamento de Estudios Psicológicos, Universidad ICESI, Cali, Colombia., Abasolo D; Centre for Biomedical Engineering, School of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK., Kilborn K; School of Psychology, University of Glasgow, Glasgow, Scotland., Rubido N; Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, AB24 3UE, UK., Clark RA; Centre for Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, UK., Herzog R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France., Yerlikaya D; Department of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey., Hu K; Harvard Medical School, Boston, USA., Parra MA; Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, United Kingdom; Researcher associate of BrainLat, Universidad Adolfo Ibáñez, Santiago, Chile., Reyes P; Pontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., García AM; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Departamento de Lingüística y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile 2., Matallana DL; Pontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia., Avila-Funes JA; Department of Geriatrics. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico., Slachevsky A; Memory and Neuropsychiatric Center (CMYN), Neurology Department, Hospital del Salvador & Faculty of Medicine, University of Chile, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program - Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile., Behrens MI; Neurology and Psychiatry Department, Clínica Alemana-Universidad Desarrollo, Santiago, Chile.; Centro de Investigación Clínica Avanzada (CICA), Facultad de Medicina-Hospital Clínico, Universidad de Chile, Independencia, Santiago, 8380453, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Independencia, Santiago, 8380430, Chile.; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Independencia, Santiago, 8380453, Chile., Custodio N; Servicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú., Cardona JF; Facultad de Psicología, Universidad del Valle, Santiago de Cali, Colombia., Barttfeld P; Cognitive Science Group. Instituto de Investigaciones Psicológicas (IIPsi), CONICET UNC, Facultad de Psicología, Universidad Nacional de Córdoba, Boulevard de la Reforma esquina Enfermera Gordillo, CP 5000. Córdoba, Argentina., Brusco IL; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina., Bruno MA; Instituto de Ciencias Biomédicas (ICBM) Facultad de Ciencias Médicas, Universidad Catoóica de Cuyo, San Juan, Argentina., Sosa Ortiz AL; Instituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico, Mexico., Pina-Escudero SD; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Takada LT; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Resende E; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Possin KL; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., de Oliveira MO; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Lopez-Valdes A; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Lawlor B; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Trinity College Dublin, The University of Dublin, Dublin, Ireland., Robertson IH; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Kosik KS; The University of Chicago, Division of the Biological Sciences, 5841 S Maryland Avenue Chicago, IL 60637, USA., Duran-Aniotz C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valcour V; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Yokoyama JS; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Miller BL; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Ibanez A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Global Brain Health Institute (GBHI), University of California, San Francisco, US; and Trinity College Dublin, Dublin, Ireland.; Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI:	10.21203/rs.3.rs-4150225/v1
Abstrakt:	Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on the brain age gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American countries -LAC, 8 non-LAC). Based on higher-order interactions in brain signals, we developed a BAG deep learning architecture for functional magnetic resonance imaging (fMRI=2,953) and electroencephalography (EEG=2,353). The datasets comprised healthy controls, and individuals with mild cognitive impairment, Alzheimer's disease, and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (fMRI: MDE=5.60, RMSE=11.91; EEG: MDE=5.34, RMSE=9.82) compared to non-LAC, associated with frontoposterior networks. Structural socioeconomic inequality and other disparity-related factors (pollution, health disparities) were influential predictors of increased brain age gaps, especially in LAC (R 2 =0.37, F 2 =0.59, RMSE=6.9). A gradient of increasing BAG from controls to mild cognitive impairment to Alzheimer's disease was found. In LAC, we observed larger BAGs in females in control and Alzheimer's disease groups compared to respective males. Results were not explained by variations in signal quality, demographics, or acquisition methods. Findings provide a quantitative framework capturing the multimodal diversity of accelerated brain aging. Competing Interests: Additional Declarations: There is NO Competing Interest. Competing Interest Statement None of the authors have competing financial or non-financial interests as defined by Nature Portfolio.
Databáze:	MEDLINE
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