Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis.

Autor: Qian YX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Rao SS; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Tan YJ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Wang Z; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Yin H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Wan TF; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., He ZH; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Wang X; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Hong CG; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Zeng HJ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Luo Y; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Duan YX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Zhu H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Hu XY; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Zou L; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Zhang Y; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Liu BB; School of Computer Science and Engineering, Central South University, Changsha, Hunan, 410083, China., Wang ZX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China., Du W; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China.; Department of Rehabilitation, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Chen CY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Xie H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep; Vol. 11 (34), pp. e2400196. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1002/advs.202400196
Abstrakt: Osteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health. Here this study shows that intermittent fasting potently relieves medial meniscus (DMM)- or natural aging-induced osteoarthritic phenotypes. Osteocytes, the most abundant bone cells, secrete excess neuropeptide Y (NPY) during osteoarthritis, and this alteration can be altered by intermittent fasting. Both NPY and the NPY-abundant culture medium of osteocytes (OCY-CM) from osteoarthritic mice possess pro-inflammatory, pro-osteoclastic, and pro-neurite outgrowth effects, while OCY-CM from the intermittent fasting-treated osteoarthritic mice fails to induce significant stimulatory effects on inflammation, osteoclast formation, and neurite outgrowth. Depletion of osteocyte NPY significantly attenuates DMM-induced osteoarthritis and abolishes the benefits of intermittent fasting on osteoarthritis. This study suggests that osteocyte NPY is a key contributing factor in the pathogenesis of osteoarthritis and intermittent fasting represents a promising nonpharmacological antiosteoarthritis method by targeting osteocyte NPY.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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