Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors - a biomarker analysis of the ALICE and ICON trials.

Autor: Andresen NK; Department of Clinical Cancer Research, Oslo University Hospital, Norway.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Norway.; Institute of Clinical Medicine, University of Oslo, Norway., Røssevold AH; Department of Clinical Cancer Research, Oslo University Hospital, Norway.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Norway.; Institute of Clinical Medicine, University of Oslo, Norway., Borgen E; Department of Pathology, Oslo University Hospital, Norway., Schirmer CB; Department of Pathology, Oslo University Hospital, Norway., Gilje B; Department of Hematology and Oncology, Stavanger University Hospital, Norway., Garred Ø; Department of Pathology, Oslo University Hospital, Norway., Lømo J; Department of Pathology, Oslo University Hospital, Norway., Stensland M; Department of Hematology and Oncology, Stavanger University Hospital, Norway., Nordgård O; Department of Hematology and Oncology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Technology, University of Stavanger, Norway., Falk RS; Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Norway., Mathiesen RR; Department of Oncology, Oslo University Hospital, Norway., Russnes HG; Institute of Clinical Medicine, University of Oslo, Norway.; Department of Pathology, Oslo University Hospital, Norway.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway., Kyte JA; Department of Clinical Cancer Research, Oslo University Hospital, Norway.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Norway.; Faculty of Health Sciences, Oslo Metropolitan University, Norway., Naume B; Institute of Clinical Medicine, University of Oslo, Norway.; Department of Oncology, Oslo University Hospital, Norway.
Jazyk: angličtina
Zdroj: Molecular oncology [Mol Oncol] 2024 Jul 08. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1002/1878-0261.13675
Abstrakt: Immune checkpoint inhibitors (ICIs) have been introduced in breast cancer (BC) treatment and better biomarkers are needed to predict benefit. Circulating tumor cells (CTCs) are prognostic in BC, but knowledge is limited on CTCs in the context of ICI therapy. In this study, serial sampling of CTCs (CellSearch system) was evaluated in 82 patients with metastatic BC enrolled in two randomized trials investigating ICI plus chemotherapy. Programmed death-ligand 1 (PD-L1) expression on CTCs was also measured. Patients with ≥ 2 CTCs per 7.5 mL at baseline had gene expression profiles in tumor suggestive of increased T-cell activity, including increased tumor inflammation signature (TIS) in both triple-negative (P = 0.010) and hormone receptor-positive (P = 0.024) disease. Patients with luminal A BC had higher CTC levels. The association between CTC status and outcome was most apparent 4 weeks into therapy. PD-L1 expression in CTCs was observed in 6/17 CTC-positive patients and was associated with inferior survival. In conclusion, our study indicates that CTC numbers may inform on tumor immune composition, as well as prognosis. These findings suggest a potential of using CTCs as an accessible biomarker source in BC patients treated with immunotherapy.
(© 2024 The Author(s). Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
Externí odkaz: