Fragile Treg cells: Traitors in immune homeostasis?

Autor: Song X; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: xiyusong@fmmu.edu.cn., Chen R; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: novababe@126.com., Li J; Student Brigade of Basic Medicine School, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: 2817405179@qq.com., Zhu Y; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: a.mu10.02@163.com., Jiao J; Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: fmmujjh@fmmu.edu.cn., Liu H; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: hongjiao826@163.com., Chen Z; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China. Electronic address: znchen@fmmu.edu.cn., Geng J; National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China; State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, PR China. Electronic address: gengjie-jie@163.com.
Jazyk: angličtina
Zdroj: Pharmacological research [Pharmacol Res] 2024 Aug; Vol. 206, pp. 107297. Date of Electronic Publication: 2024 Jul 06.
DOI: 10.1016/j.phrs.2024.107297
Abstrakt: Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression. Fragile Treg cells are formatively, phenotypically and functionally diverse in various diseases, further complicating the role of Treg cells in the immunotherapeutic response and offering novel targets for disease treatment by modulating specific Treg subsets. In this review, we summarize findings on fragile Treg cells to provide a framework for characterizing the formation and role of fragile Treg cells in different diseases, and we discuss how this information may guide the development of more specific Treg-targeted immunotherapies.
Competing Interests: Declaration of Competing Interest No conflict of interest exits in the submission of this manuscript.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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