Cardiac safety of ribociclib evaluated with 24-hour rhythm Holter electrocardiogram.

Autor: Yasin AI; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey. ayseiremyasin@gmail.com., Uluganyan M; Department of Cardiology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Isleyen ZS; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Topcu A; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Shbair AT; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Simsek M; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Besiroglu M; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Ersoy YE; Department of General Surgery, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad. , 34396, Istanbul, Turkey., Türk HM; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey., Seker M; Department of Medical Oncology, Bezmialem Vakıf University, Huzur Mah. Cumhuriyet Cad., 34396, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2024 Jul 08; Vol. 32 (8), pp. 492. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1007/s00520-024-08702-0
Abstrakt: Objective: We aimed to evaluate cardiac safety profile of ribociclib with 24-h rhythm Holter ECG.
Material and Method: Forty-two female metastatic breast cancer patients were included in the study. Rhythm Holter ECG was performed before starting treatment with ribociclib and after 3 months of the treatment initiation.
Results: The mean age of the patients was 56.36 ± 12.73. 52.4% (n = 22) of the patients were using ribociclib in combination with fulvestrant and 47.6% (n = 20) with aromatase inhibitors. None of the patients developed cardiotoxicity. When the rhythm Holter results before and in third month of the treatment were compared, there was no statistically significant difference.
Conclusion: This is the first study evaluating effects of ribociclib treatment on cardiac rhythm with Holter ECG. The findings suggested ribociclib has a low risk of causing early cardiotoxicity.
(© 2024. The Author(s).)
Databáze: MEDLINE
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