Sirtuin insights: bridging the gap between cellular processes and therapeutic applications.

Autor: Kamal S; Department of Biochemistry, Government College University, Faisalabad, Pakistan., Babar S; Department of Biochemistry, Government College University, Faisalabad, Pakistan., Ali W; Department of Biochemistry, Government College University, Faisalabad, Pakistan., Rehman K; Department of Pharmacy, The Women University, Multan, Pakistan., Hussain A; Institute of Chemistry, University of Okara, Okara, Punjab, Pakistan., Akash MSH; Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan. sajidakash@gcuf.edu.pk.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Dec; Vol. 397 (12), pp. 9315-9344. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1007/s00210-024-03263-9
Abstrakt: The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD + -dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethical approval: N/A.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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