Pseudomicroangiopathic Thrombotic Syndrome: Unveiling the Vitamin B12 Deficiency Connection.

Autor:	Sabri S; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR., Aqodad Z; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR., Alaoui H; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR., Bachir H; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR., Hamaz S; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR., Serraj K; Department of Internal Medicine, Immuno-Hematology and Cellular Therapy Laboratory, Faculty of Medicine and Pharmacy, University Hospital Mohammed Vl, Mohammed First University, Oujda, MAR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 06; Vol. 16 (6), pp. e61787. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).
DOI:	10.7759/cureus.61787
Abstrakt:	Pernicious anemia, a manifestation of vitamin B12 deficiency, can present with a spectrum of hematological abnormalities, sometimes mimicking more severe conditions such as thrombotic microangiopathy (TMA). This case report details a 53-year-old female who presented with significant weight loss, watery diarrhea, and jaundice. Laboratory investigations revealed pancytopenia, hemolysis, and schistocytes, initially suggesting a diagnosis of microangiopathic hemolytic anemia (MAHA). However, significantly low vitamin B12 levels and subsequent bone marrow examination confirmed pernicious anemia with megaloblastic changes. This case underscores the importance of considering vitamin B12 deficiency in the differential diagnosis of patients presenting with TMA-like symptoms. Early recognition and treatment with vitamin B12 supplementation led to rapid clinical improvement and the resolution of symptoms. This report highlights the need for heightened clinical awareness of atypical presentations of pernicious anemia to prevent misdiagnosis and ensure timely, effective treatment. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Sabri et al.)
Databáze:	MEDLINE
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