No evidence on infectious DNA-based agents in pediatric acute lymphoblastic leukemia using whole metagenome shotgun sequencing.
| Autor: | Heinz AT; Department of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany.; Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin (Olgahospital), Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie), Klinikum der Landeshauptstadt Stuttgart, Stuttgart, Germany., Grumaz S; Noscendo GmbH, Duisburg, Germany., Slavetinsky C; Department of Pediatric Surgery and Urology, University Children´s Hospital Tuebingen, Tuebingen, Germany., Döring M; Department of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany., Queudeville M; Department for Stem Cell Transplantation and Immunology, Klinikum Hamburg-Eppendorf (UKE), Hamburg, Germany., Handgretinger R; Abu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates., Ebinger M; Department of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Jun 21; Vol. 14, pp. 1355787. Date of Electronic Publication: 2024 Jun 21 (Print Publication: 2024). |
| DOI: | 10.3389/fcimb.2024.1355787 |
| Abstrakt: | The etiology of pediatric acute lymphatic leukemia (ALL) is still unclear. Whole-metagenome shotgun sequencing of bone marrow samples in patients with treatment-naïve ALL (n=6) was performed for untargeted investigation of bacterial and viral DNA. The control group consisted of healthy children (n=4) and children with non-oncologic diseases (n=2) undergoing bone marrow sampling. Peripheral blood of all participants was investigated at the same time. After bioinformatical elimination of potential contaminants by comparison with the employed controls, no significant amounts of microbial or viral DNA were identified. Competing Interests: Author SG was employed by the company Noscendo GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Heinz, Grumaz, Slavetinsky, Döring, Queudeville, Handgretinger and Ebinger.) |
| Databáze: | MEDLINE |
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