Quality of life of pediatric patients with craniopharyngioma: A retrospective series from a low-middle-income country with more than 4 years follow-up.

Autor:	Baqai MWS; Department of Neurosurgery, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom., Shah Z; Dean's Clinical Research Program, Aga Khan University, Aga Khan University Hospital, Karachi, Sindh, Pakistan., Malik MJA; Aga Khan Medical College, Aga Khan University, Karachi, Sindh, Pakistan., Zia N; Aga Khan Medical College, Aga Khan University, Karachi, Sindh, Pakistan., Shafqat S; Aga Khan Medical College, Aga Khan University, Karachi, Sindh, Pakistan., Zahid N; Department of Surgery, Aga Khan University, Aga Khan University Hospital, Karachi, Sindh, Pakistan., Shamim MS; Department of Neurosurgery, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom.
Jazyk:	angličtina
Zdroj:	Surgical neurology international [Surg Neurol Int] 2024 Jun 14; Vol. 15, pp. 199. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).
DOI:	10.25259/SNI_186_2024
Abstrakt:	Background: Craniopharyngiomas (CPs) are rare, low-grade tumors characterized by a range of debilitating symptoms. Most of the existing literature reports postoperative outcomes of the different treatment modalities of childhood CP. However, few studies have reported the impact of these different treatment methods on the quality of life (QoL) of survivors of childhood CP. Therefore, we aim to assess the correlation between different surgical modalities on the QoL of patients with childhood CP from a lower-middle-income country. Methods: Twenty-nine survivors who underwent treatment for CP were included in the study. The selected patients had either been managed with complete resection, debulking, or placement of an Ommaya reservoir. QoL was assessed by the pediatric quality of life (PedsQL) questionnaire. The effect of the different treatment modalities on the QoL was assessed. Results: Mean follow-up was 4.4 ± 2.19 years. The type of surgery was significantly related to the mean PedsQL scores for the total score as well as each of the individual domain scores ( P < 0.001). Complete resection of the tumor resulted in the lowest mean (standard deviation) PedsQL total score of 56.6 ± 7.12 compared to the Ommaya reservoir with biopsy (83.3 ± 5.69) and debulking (93.8 ± 3.37) ( P < 0.001). Conclusion: There was a significant effect of the type of surgical treatment on the QoL of the survivors of childhood CP. It is important to consider the long-term outcomes in addition to immediate postoperative outcomes when deciding on a treatment strategy while managing children with CP. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Surgical Neurology International.)
Databáze:	MEDLINE
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