Analysis of antibiotic regimens and outcomes in spinal brucellosis: insights from a retrospective cohort study in Makkah, Saudi Arabia.

Autor:	Aljuaid AS; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Badirah SB; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Abusaeed RI; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Almalki AM; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Almaghrabi MA; Department of Preventive Medicine, Ministry of Health, Makkah, Saudi Arabia., Alzahrani EA; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Alhazmi KA; College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Almaghrabi AA; Department of Radiology, Al-Noor Specialist Hospital, Makkah, Saudi Arabia., AlQarni AM; Department of Internal Medicine, Al-Noor Specialist Hospital, Makkah, Saudi Arabia., Alghamdi KM; Department of Orthopedic Surgery, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Journal of spine surgery (Hong Kong) [J Spine Surg] 2024 Jun 21; Vol. 10 (2), pp. 264-273. Date of Electronic Publication: 2024 May 08.
DOI:	10.21037/jss-23-104
Abstrakt:	Background: Brucellosis is a zoonotic disease that is widely spread across the globe, with the number of cases increasing annually. Spinal brucellosis is known to affect about half of patients with brucellosis. Nevertheless, data on the optimal antibiotic regimens for spinal brucellosis are limited. Therefore, this study aims to compare antibiotic treatment regimens for spinal brucellosis at our center in Makkah, Saudi Arabia. Methods: This is a retrospective cohort study of an 11-year period from 2010 to 2021 conducted at a single center in Makkah, Saudi Arabia. All patients with spinal brucellosis were included. Patients were excluded if the duration of the received antibiotic regimen or follow-up was poorly documented. Data analysis was conducted using RStudio (R version 4.1.1). Categorical variables of each regimen used by the patients were presented as frequencies and percentages, while numerical variables were summarized using the median and interquartile range (IQR). Results: A total of 35 patients were included; the median (IQR) age of the patients was 58.0 (48.0 to 63.0) years. The most frequently reported symptoms upon admission included low back pain (83.3%). The most frequently administered regimen was the combination of streptomycin + doxycycline + rifampicin (SDR) (20 patients, 55.6%), followed by the combination of streptomycin + rifampicin + trimethoprim/sulfamethoxazole (SRT) (eight patients, 22.2%). Overall, out of the total 35 patients who received first-line treatment, only six patients experienced therapy failure. Out of the total six patients who experienced first-line treatment failure with SDR (five patients, 83%) and SDT (one patient, 17%), surgery was indicated for three patients. Surgical intervention was deemed necessary in 12 patients (34%). Three patients chose not to undergo surgical intervention but still showed complete improvement upon completing the treatment duration. One patient experienced a postoperative complication, resulting in paraplegia. Conclusions: In this study, we found that among 35 patients, treatment failure was observed only in six patients who received triple therapy. In addition, surgical intervention was indicated in 12 patients; however, three patients refused surgery and improved ultimately after changing or extending the duration of the antibiotic regimen. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jss.amegroups.com/article/view/10.21037/jss-23-104/coif). The authors have no conflicts of interest to declare. (2024 Journal of Spine Surgery. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu