Clinical Challenges and Management Strategies in Pulmonary Large-Cell Neuroendocrine Carcinoma.
| Autor: | Untalan AD; Internal Medicine, Rutgers Health/Monmouth Medical Center, Long Branch, USA., Arty F; Internal Medicine, Rutgers Health/Monmouth Medical Center, Long Branch, USA., Khan MA; Internal Medicine, Rutgers Health/Monmouth Medical Center, Long Branch, USA., Sirpal V; Internal Medicine, Rutgers Health/Monmouth Medical Center, Long Branch, USA., Shah SM; Internal Medicine, Rutgers Health/Monmouth Medical Center, Long Branch, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jul 03; Vol. 16 (7), pp. e63781. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.63781 |
| Abstrakt: | Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare but aggressive malignancy of the lung. Its nonspecific presentation and propensity for severe disease at the time of diagnosis create challenges in treatment. We report a case of an asymptomatic 61-year-old female who was incidentally found to have a pulmonary nodule after a fall. Upon further workup, she was found to have an aggressive LCNEC. The patient underwent a robotic-assisted left upper lobectomy, which was complicated by left lower lobe bronchus kinking and post-obstructive atelectasis, warranting further management by thoracic surgery. The patient additionally underwent video-assisted thoracoscopic surgery (VATS), open thoracotomy, pneumopexy, and bronchial stenting. This case highlights the need for strategies for early detection in at-risk populations. A multidisciplinary approach, which may involve both medical and surgical subspecialties, is essential in the management of this complex disease from the time of diagnosis to follow-up postoperatively to achieve the best clinical outcome. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Untalan et al.) |
| Databáze: | MEDLINE |
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