Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms.

Autor:	Domacassé D; From the Amsterdam UMC, location Vrije Universiteit Amsterdam, Midwifery Science (de Jonge, Henrichs); Midwifery Academy Amsterdam Groningen, InHolland (de Jonge, Henrichs); Amsterdam Public Health, Mental Health (de Jonge, Henrichs), Amsterdam; Department of Primary and Long-term Care, University Medical Center Groningen, University of Groningen (Domacassé, de Jonge, Henrichs), Groningen; Amsterdam UMC location University of Amsterdam, Epidemiology and Data Science (de Rooij); Amsterdam UMC location University of Amsterdam, Reproduction and Development Research Institute (de Rooij, Vrijkotte); Amsterdam UMC location University of Amsterdam, Amsterdam Public Health Research Institute, Aging and Later Life, Health Behaviors and Chronic Diseases (de Rooij, Vrijkotte); and Amsterdam UMC, Department of Public and Occupational Health, University of Amsterdam (Vrijkotte), Amsterdam, the Netherlands., de Rooij SR, Vrijkotte T, de Jonge A, Henrichs J
Jazyk:	angličtina
Zdroj:	Psychosomatic medicine [Psychosom Med] 2024 Sep 01; Vol. 86 (7), pp. 648-657. Date of Electronic Publication: 2024 Jul 03.
DOI:	10.1097/PSY.0000000000001328
Abstrakt:	Objective: Maternal postpartum depressive and anxiety symptoms are risk factors for subsequent maternal and child mental health problems. Little is known about the potential role of antepartum vitamin D and C-reactive protein (CRP) in the etiology of maternal postpartum affective symptoms. We investigated associations between antepartum vitamin D status and postpartum depressive and anxiety symptoms and whether antepartum CRP mediated these associations. Methods: In 2483 participants of the Amsterdam Born Children and their Development prospective cohort, maternal serum vitamin D and CRP were measured at a median of 13 weeks' gestation. Vitamin D status was defined as deficient (≤29.9 nM), insufficient (30-49.9 nM), sufficient (50-79.9 nM), or normal (≥80 nM). Maternal depressive symptoms (Center for Epidemiologic Studies-Depression) and anxiety (State-Trait Anxiety Inventory) were assessed 3 months postpartum. Results: After adjustments for confounders, vitamin D deficiency was only associated with increased postpartum anxiety symptoms ( B = 0.17, 95% confidence interval [CI] = 0.03-0.30, p = .017) compared to normal vitamin D levels (≥80 nM). In women not taking vitamin D supplementation ( n = 2303), vitamin D deficiency was associated with increased postpartum depressive and anxiety symptoms ( B = 0.14, 95% CI = 0.03-0.28, p = .045; and B = 0.17, 95% CI = 0.03-0.32, p = .015). Antepartum CRP did not mediate these links. Conclusions: We found some evidence that antepartum vitamin D deficiency was associated with increased postpartum affective symptoms, especially in women not taking vitamin D supplementation. Clinical trials should determine whether vitamin D supplementation can reduce the risk for postpartum affective disorders. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society.)
Databáze:	MEDLINE
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