Immunophenotyping and viral studies in pityriasis lichenoides et varioliformis acuta lesions.

Autor: Mishlab S; Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel.; Department of Pathology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel., Avitan-Hersh E; Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel., Zohar Y; Department of Pathology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel., Szwarcwort-Cohen M; Department of Microbiology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel., Bergman R; Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel.; Department of Pathology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2024 Oct; Vol. 51 (10), pp. 790-798. Date of Electronic Publication: 2024 Jul 07.
DOI: 10.1111/cup.14679
Abstrakt: Background: The underlying pathogenesis of pityriasis lichenoides et varioliformis acuta (PLEVA) remains unclear, although immunologic injury and viral etiology have been suggested.
Objective: To evaluate and expand the immunophenotype of PLEVA and to search for possible viral pathogens.
Methods: Formalin-fixed, paraffin-embedded specimens of 20 patients with PLEVA and 9 patients with common inflammatory dermatoses (ID) were studied for immunophenotyping and for human herpesvirus (HHV) 1 and 2, cytomegalovirus (CMV), HHV-8, parvovirus B19, and Epstein-Barr virus (EBV) immunohistochemistry. The presence of HHV-6, HHV-7, and enteroviruses was assayed molecularly.
Results: The numbers of CD8 + T cells and T-cell intracellular antigen-1 (TIA-1) + cells were statistically significantly higher in PLEVA compared to the ID group. Immunohistochemistry for human HHV-1 and HHV-2, CMV and HHV-8, parvovirus B19, and in situ hybridization for EBV were all negative. There was molecular evidence for HHV-7 in only one PLEVA case (5%). Molecular studies for HHV-6 and enterovirus involvement were negative in all the PLEVA specimens.
Conclusions: The predominant T-cell infiltrate in PLEVA is dominated by CD8 + cells, and by increased numbers of TIA1 + cells, which may indicate a cytotoxic T-cell damage to the epidermis. Viral presence was not detected.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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