[Advances in glucocorticoid resistance in otorhinolaryngological diseases].
| Autor: | Li Y; Department of Otorhinolaryngology，Head and Neck Surgery，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University，Nanjing，210008，China., She W; Department of Otorhinolaryngology，Head and Neck Surgery，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University，Nanjing，210008，China. |
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| Jazyk: | čínština |
| Zdroj: | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2024 Jul; Vol. 38 (7), pp. 661-665. |
| DOI: | 10.13201/j.issn.2096-7993.2024.07.020 |
| Abstrakt: | Glucocorticoids（GC） are widely used in the clinical treatment of autoimmune inner ear diseases, sudden sensorineural hearing loss, Meniere's disease, sinusitis and other otolaryngology diseases. However, GC resistance remains a major factor contributing to the poor efficacy of clinical treatments. The mechanism of GC resistance is still unclear. This paper reviews the related mechanisms of GC resistance from the perspectives of GC receptor factors and non-GC receptor factors. Additionally, it summarizes the latest research progress on GC resistance in otolaryngological diseases, with the aim of identifying effective clinical alternative treatment options for reversing GC resistance in the future. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.) |
| Databáze: | MEDLINE |
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