Neuronal network controlling REM sleep.

Autor: Luppi PH; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France.; University Lyon 1, Lyon, France., Malcey J; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France.; University Lyon 1, Lyon, France., Chancel A; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France.; University Lyon 1, Lyon, France., Duval B; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France., Cabrera S; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France.; University Lyon 1, Lyon, France., Fort P; INSERM, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Team 'Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil', Lyon, France.; University Lyon 1, Lyon, France.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2024 Jul 07, pp. e14266. Date of Electronic Publication: 2024 Jul 07.
DOI: 10.1111/jsr.14266
Abstrakt: Rapid eye movement sleep is a state characterized by concomitant occurrence of rapid eye movements, electroencephalographic activation and muscle atonia. In this review, we provide up to date knowledge on the neuronal network controlling its onset and maintenance. It is now accepted that muscle atonia during rapid eye movement sleep is due to activation of glutamatergic neurons localized in the pontine sublaterodorsal tegmental nucleus. These neurons directly project and excite glycinergic/γ-aminobutyric acid-ergic pre-motoneurons localized in the ventromedial medulla. The sublaterodorsal tegmental nucleus rapid eye movement-on neurons are inactivated during wakefulness and non-rapid eye movement by rapid eye movement-off γ-aminobutyric acid-ergic neurons localized in the ventrolateral periaqueductal grey and the adjacent dorsal deep mesencephalic reticular nucleus. Melanin-concentrating hormone and γ-aminobutyric acid-ergic rapid eye movement sleep-on neurons localized in the lateral hypothalamus would inhibit these rapid eye movement sleep-off neurons initiating the state. Finally, the activation of a few limbic cortical structures during rapid eye movement sleep by the claustrum and the supramammillary nucleus as well as that of the basolateral amygdala would be involved in the function(s) of rapid eye movement sleep. In summary, rapid eye movement sleep is generated by a brainstem generator controlled by forebrain structures involved in autonomic control.
(© 2024 European Sleep Research Society.)
Databáze: MEDLINE
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