Embolization of the Pancreas Using Microspheres: A Proof-of-Safety Study in a Porcine Model.
| Autor: | Cline B; Department of Radiology, Duke University Medical Center, Durham, North Carolina. Electronic address: brendan.cline@duke.edu., Meyerhoff RR; Department of Radiology, Duke University Medical Center, Durham, North Carolina., Everitt J; Department of Pathology, Duke University School of Medicine, Durham, North Carolina., Kim CY; Department of Radiology, Duke University Medical Center, Durham, North Carolina. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2024 Oct; Vol. 35 (10), pp. 1544-1550. Date of Electronic Publication: 2024 Jul 06. |
| DOI: | 10.1016/j.jvir.2024.06.034 |
| Abstrakt: | Purpose: To evaluate safety and impact of particle embolization on pancreatic function in a pig model. Materials and Methods: Embolization of the dorsal pancreatic artery using 100-300-μm particles was performed on 14 Yorkshire pigs. Baseline and post-embolization glucose tolerance testing results and serum amylase/lipase levels were obtained. Pigs were observed for 2 weeks to assess for behavioral signs of pain/distress, bowel changes, and changes to intake/output. After 2 weeks, euthanasia and necropsy with gross and histopathologic assessment of the pancreas were performed. Results: Embolization was technically successful in all pigs. All animals survived the 2-week follow-up without evidence of pain/distress. There were significant increases in amylase and lipase at 24 and 48 hours (P < .001), which normalized by 2 weeks. There was minimal change in glucose tolerance testing at 2 weeks. Bowel habits were unchanged without diarrhea. At necropsy, all examined pancreases had fibrosis in the distal body and tail, without gross evidence of ongoing inflammation. On histopathologic evaluation, all pancreases demonstrated fibrosis in the embolized portions without evidence of active inflammation in treated or adjacent pancreatic tissue. Conclusions: Particle embolization of the pancreas was feasible and tolerated by all tested pigs with transient amylasemia, lipasemia, and mildly impaired glucose tolerance but without clinical or histopathologic evidence of acute pancreatitis and no evident impact on pancreatic endocrine or exocrine function. (Copyright © 2024 SIR. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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