Vitifolignans, 3,4-dibenzyltetrahydrofuran lignans from Anemone vitifolia Buch.-Ham.

Autor: Lu Y; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China., Huang X; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China., Adpressa DA; Loxo Oncology, Louisville, CO, 80027, United States., Mou L; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, Tianjin, PR China., Taylor PR; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China., Clark BR; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China. Electronic address: bclark@tju.edu.cn.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2024 Oct; Vol. 226, pp. 114217. Date of Electronic Publication: 2024 Jul 06.
DOI: 10.1016/j.phytochem.2024.114217
Abstrakt: Anemone vitifolia is a small herb found in Asia that is used to treat a range of diseases in Chinese traditional medicine. GNPS-based molecular networking of an Anemone vitifolia specimen revealed the presence of a network containing numerous ions indicating the presence of lignans, several of which suggested that there might be previously undescribed compounds in the extract. Fractionation of the organic extract yielded five undescribed lignans, the vitifolignans, together with one known. The structures were identified based on extensive spectroscopic data analysis (NMR, HR-ESI-MS, and UV), coupling constant calculation and comparison with reported data. Their absolute configurations were determined by comparison of experimental ECD spectra with calculated spectra. Compounds 4/5 showed weak inhibition of LPS-induced NO production in mouse mononuclear macrophages.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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