Photobiomodulation transiently increases the spontaneous firing in the superficial layer of the rat spinal dorsal horn.

Autor: Ishibashi N; Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan; Bio-medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, 191-8512, Japan., Uta D; Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan. Electronic address: daicarp@pha.u-toyama.ac.jp., Sawahata M; Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan., Kume T; Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Oct 15; Vol. 729, pp. 150362. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1016/j.bbrc.2024.150362
Abstrakt: The therapeutic benefits of photobiomodulation (PBM) in pain management, although well documented, are accompanied by concerns about potential risks, including pain, particularly at higher laser intensities. This study investigated the effects of laser intensity on pain perception using behavioral and electrophysiological evaluations in rats. Our results show that direct laser irradiation of 1000 mW/cm 2 to the sciatic nerve transiently increases the frequency of spontaneous firing in the superficial layer without affecting the deep layer of the spinal dorsal horn, and this effect reverses to pre-irradiation levels after irradiation. Interestingly, laser irradiation at 1000 mW/cm 2 , which led to an increase in spontaneous firing, did not prompt escape behavior. Furthermore, a significant reduction in the time to initiate escape behavior was observed only at 9500 mW/cm 2 compared to 15, 510, 1000, and 4300 mW/cm 2 . This suggests that 1000 mW/cm 2 , the laser intensity at which an increase in spontaneous firing was observed, corresponds to a stimulus that did not cause pain. It is expected that a detailed understanding of the risks and mechanisms of PBM from a neurophysiological perspective will lead to safer and more effective use of PBM.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Daisuke Uta reports financial support was provided by Teijin Pharma Limited and KAKENHI (22K09020, 19K09323). Naoya Ishibashi reports financial support was provided by Teijin Pharma Limited. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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