Unraveling diabetes complexity through natural products, miRNAs modulation, and future paradigms in precision medicine and global health.

Autor: Nurkolis F; Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, Indonesia. Electronic address: fahrul.nurkolis.mail@gmail.com., Wiyarta E; Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National 13 Hospital, Jakarta 10430, Indonesia., Taslim NA; Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia., Kurniawan R; Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia., Thibault R; Department of Endocrinology Diabetology and Nutrition, CHU Rennes, Nutrition-Metabolisms-Cancer (NuMeCan) Institute, INSERM, INRAE, Univ Rennes, Rennes, France., Fernandez ML; Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA; School of Nutrition and Wellness, University of Arizona, Tucson, AZ 85721, USA., Yang Y; National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China; Chinese Nutrition Society, Beijing 100022, China., Han J; National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China., Tsopmo A; Food Science and Nutrition Program, Department of Chemistry, Carleton University, Ottawa, Canada; Institute of Biochemistry, Carleton University, Ottawa, ON K1S 5B6, Canada., Mayulu N; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado 95249, Indonesia., Tjandrawinata RR; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia., Tallei TE; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado 95115, Indonesia., Hardinsyah H; Division of Applied Nutrition, Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java 16680, Indonesia.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2024 Oct; Vol. 63, pp. 283-293. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1016/j.clnesp.2024.06.043
Abstrakt: Background and Aims: The challenge posed by diabetes necessitates a paradigm shift from conventional diagnostic approaches focusing on glucose and lipid levels to the transformative realm of precision medicine. This approach, leveraging advancements in genomics and proteomics, acknowledges the individualistic genetic variations, dietary preferences, and environmental exposures in diabetes management. The study comprehensively analyzes the evolving diabetes landscape, emphasizing the pivotal role of genomics, proteomics, microRNAs (miRNAs), metabolomics, and bioinformatics.
Results: Precision medicine revolutionizes diabetes research and treatment by diverging from traditional diagnostic methods, recognizing the heterogeneous nature of the condition. MiRNAs, crucial post-transcriptional gene regulators, emerge as promising therapeutic targets, influencing key facets such as insulin signaling and glucose homeostasis. Metabolomics, an integral component of omics sciences, contributes significantly to diabetes research, elucidating metabolic disruptions, and offering potential biomarkers for early diagnosis and personalized therapies. Bioinformatics unveils dynamic connections between natural substances, miRNAs, and cellular pathways, aiding in the exploration of the intricate molecular terrain in diabetes. The study underscores the imperative for experimental validation in natural product-based diabetes therapy, emphasizing the need for in vitro and in vivo studies leading to clinical trials for assessing effectiveness, safety, and tolerability in real-world applications. Global cooperation and ethical considerations play a pivotal role in addressing diabetes challenges worldwide, necessitating a multifaceted approach that integrates traditional knowledge, cultural competence, and environmental awareness.
Conclusions: The key components of diabetes treatment, including precision medicine, metabolomics, bioinformatics, and experimental validation, converge in future strategies, embodying a holistic paradigm for diabetes care anchored in cutting-edge research and global healthcare accessibility.
Competing Interests: Declaration of competing interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors report no relationships that could be construed as a conflict of interest.
(Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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