EGFR-TKI-induced Factor V deficiency in a patient with advanced non-small cell lung cancer: The first case report.

Autor: Yoshizaki C; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Yoshida Y; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Nohmi S; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Go Y; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Kusakado R; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Kawamura S; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Inoue D; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Kabasawa N; Department of Hematology, Showa University Fujigaoka Hospital, Yokohama, Japan., Yamaguchi F; Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan. Electronic address: f_y@med.showa-u.ac.jp.
Jazyk: angličtina
Zdroj: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2024 Aug; Vol. 194, pp. 107869. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1016/j.lungcan.2024.107869
Abstrakt: Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is routinely prescribed as first-line therapy for advanced non-small cell lung cancer, regardless of the presence of the T790M resistance mutation. This study reports a rare case of Factor V inhibitor detection during osimertinib therapy in a patient with lung adenocarcinoma. These findings underscore the importance of vigilant monitoring for coagulation abnormalities during EGFR-TKI therapy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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