Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.

Autor: Ma Q; Department of Nephrology, Tai'an Maternal and Child Health Hospital, Tai'an, China., Li YQ; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, China., Meng QT; Department of Obstetrics, Tai'an Maternal and Child Health Hospital, Tai'an, China., Yang B; Department of Color Ultrasound, Tai'an Maternal and Child Health Hospital, Tai'an, China., Zhang HT; Department of Neonatology, Tai'an Maternal and Child Health Hospital, Tai'an, China., Shi H; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, China., Liu CY; Department of Nephrology, Tai'an Maternal and Child Health Hospital, Tai'an, China., Xiang TC; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, China.; Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China.; Shanghai Key Lab of Birth Defect, Children's Hospital of Fudan University, Shanghai, China., Zhao N; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, China. xiangxmu@qq.com.; Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China. xiangxmu@qq.com.; Shanghai Key Lab of Birth Defect, Children's Hospital of Fudan University, Shanghai, China. xiangxmu@qq.com., Rao J; Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, China. jiarao@fudan.edu.cn.; Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China. jiarao@fudan.edu.cn.; Shanghai Key Lab of Birth Defect, Children's Hospital of Fudan University, Shanghai, China. jiarao@fudan.edu.cn.; National Key Laboratory of Kidney Diseases, Beijing, China. jiarao@fudan.edu.cn.
Jazyk: angličtina
Zdroj: World journal of pediatrics : WJP [World J Pediatr] 2024 Nov; Vol. 20 (11), pp. 1168-1178. Date of Electronic Publication: 2024 Jul 06.
DOI: 10.1007/s12519-024-00822-1
Abstrakt: Background: Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.
Methods: This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center. Medical information on maternal noncommunicable diseases, including obesity, hypertension, diabetes mellitus, kidney disease, hyperthyroidism, hypothyroidism, psychiatric disease, epilepsy, cancer, and autoimmune disease was collected. Based on the records of ultrasound scanning during the third trimester, the diagnosis was classified as isolated urinary tract dilation (UTD) or kidney anomalies. Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.
Results: Among the 19,656 pregnant women, perinatal ultrasound detected suspicious CAKUT in 114 (5.8/1000) fetuses, comprising 89 cases with isolated UTD and 25 cases with kidney anomalies. The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes, thyroid dysfunction, neuropsychiatric disease, anemia, ovarian and uterine disorders. A prediction model for isolated UTD was developed utilizing four confounding factors, namely gestational diabetes, gestational hypertension, maternal thyroid dysfunction, and hepatic disease. Similarly, a separate prediction model for kidney anomalies was established based on four distinct confounding factors, namely maternal thyroid dysfunction, gestational diabetes, disorders of ovarian/uterine, and kidney disease.
Conclusions: Isolated UTD and kidney anomalies were associated with different maternal diseases. The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.
Competing Interests: Declarations. Ethical approval: Due to the retrospective nature of the study, informed consent was waived. All the procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethical Committee for scientific research approval of the Tai’an Hospital (TA-2019-027). Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. The authors have no conflict of interest relevant to this article to declare.
(© 2024. The Author(s).)
Databáze: MEDLINE
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