Neonatal phototherapy and risk of epilepsy-A Danish population based study.

Autor: Sun Y; Department of Neurology, Department of Clinical Medicine, Aarhus University Hospital, Affiliated Member of the European Reference Network EpiCARE, Aarhus, Denmark. ys@clin.au.dk.; Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark. ys@clin.au.dk.; National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark. ys@clin.au.dk., Dreier JW; National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.; Centre for Integrated Register-Based Research (CIRRAU), Aarhus University, Aarhus, Denmark., Wu C; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark., Petersen JP; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Henriksen TB; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Christensen J; Department of Neurology, Department of Clinical Medicine, Aarhus University Hospital, Affiliated Member of the European Reference Network EpiCARE, Aarhus, Denmark.; National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Maimburg RD; Department of Clinical Medicine & Occupational Health, Aarhus University Hospital, Aarhus, Denmark.; Department of Midwifery, University College of Northern Denmark, Aalborg, Denmark.; School of Nursing and Midwifery. Western, Sydney University, Sydney, Australia.
Jazyk: angličtina
Zdroj: European journal of pediatrics [Eur J Pediatr] 2024 Sep; Vol. 183 (9), pp. 4111-4121. Date of Electronic Publication: 2024 Jul 06.
DOI: 10.1007/s00431-024-05681-6
Abstrakt: To evaluate the risk of epilepsy in children who received neonatal phototherapy. A cohort of live singletons born at a Danish hospital (2002-2016) with a gestational age ≥ 35 weeks. We used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of epilepsy in children treated with neonatal phototherapy compared to children not treated with neonatal phototherapy in the general population, and in a subpopulation of children who had serum bilirubin measurement. Adjusted HRs (aHR) were computed using multivariable and propensity score matching models to take maternal and neonatal factors into consideration. Children were followed from day 29 after birth to diagnosis of epilepsy, death, emigration, or December 31, 2016. Among 65,365 children, 958 (1.5%) received neonatal phototherapy. Seven children (incidence rates (IRs): 10.8 /10,000 person-years) who received neonatal phototherapy and 354 children (IR: 7.7) who did not receive neonatal phototherapy were diagnosed with epilepsy. Neonatal phototherapy was not associated with an increased risk of epilepsy using the multivariable (aHR 0.95, 95% CI: 0.43-2.09) and propensity score matched (aHR 0.94, 95% CI: 0.39-2.28) models. In the subpopulation of 9,378 children with bilirubin measurement, 928 (9.9%) received neonatal phototherapy. In the analysis of the subpopulation in which bilirubin level and age at the time of bilirubin measurement were further taking into consideration, neonatal phototherapy was not associated with an increased risk of epilepsy using the multivariable (aHR 1.26, 95% CI: 0.54-2.97) and propensity score matched (aHR 1.24, 95% CI: 0.47-3.25) models,Conclusions: Neonatal phototherapy was not associated with an increased risk of epilepsy after taking maternal and neonatal factors into consideration. What is known: • A few studies have suggested that neonatal phototherapy for hyperbilirubinemia may increase the risk of childhood epilepsy. • Whether the observed associations contribute to hyperbilirubinemia, phototherapy, or underlying factors requires further investigation. What is new: • This study revealed no increased risk of epilepsy in children treated with neonatal phototherapy compared to children not treated with phototherapy after taking maternal and neonatal factors into consideration. • After further taking bilirubin level and age at the time of bilirubin measurement into consideration, neonatal phototherapy was not associated with an increased risk of epilepsy.
(© 2024. The Author(s).)
Databáze: MEDLINE