The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis.

Autor: Zoroddu S; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Di Lorenzo B; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Paliogiannis P; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.; Anatomic Pathology and Histology Unit, University Hospital (AOU) of Sassari, Sassari, Italy., Mangoni AA; Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Bedford Park, South Australia, Australia., Carru C; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.; Medical Oncology Unit, University Hospital (AOU) of Sassari, Sassari, Italy., Zinellu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Jazyk: angličtina
Zdroj: European journal of clinical investigation [Eur J Clin Invest] 2024 Nov; Vol. 54 (11), pp. e14281. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1111/eci.14281
Abstrakt: Background: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), poses a significant challenge to health care systems because of its chronic nature and increasing global prevalence. Effective management of IBD requires accurate diagnostic tools and biomarkers. This systematic review and meta-analysis aimed to evaluate the relationship between bilirubin concentrations and IBD activity and outcomes.
Methods: A comprehensive search of electronic databases identified 11 studies that included 2606 subjects with IBD and 3607 healthy controls.
Results: Bilirubin concentrations were significantly lower in subjects with IBD when compared to controls (SMD = -0.96, 95% CI -1.21 to -0.70; p < .001). Although substantial heterogeneity was observed, sensitivity analysis confirmed the robustness of the results. Publication bias was detected, but subgroup analyses did not significantly alter the results. Meta-regression showed that age was a significant factor influencing the association between bilirubin concentrations and IBD. Subgroup analyses showed a more pronounced reduction in bilirubin concentrations in subjects with CD than those with UC.
Conclusion: This study supports the potential utility of bilirubin as a biomarker in IBD, emphasizing the need for further research to validate its clinical significance.
(© 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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