The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm.

Autor: Vo TTT; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam., Peng TY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan., Nguyen TH; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam., Bui TNH; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam., Wang CS; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan., Lee WJ; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei, 110301, Taiwan., Chen YL; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan., Wu YC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan., Lee IT; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan. itlee0128@tmu.edu.tw.
Jazyk: angličtina
Zdroj: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Jul 05; Vol. 22 (1), pp. 353. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1186/s12964-024-01726-3
Abstrakt: Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.
(© 2024. The Author(s).)
Databáze: MEDLINE
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