Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged Baladi bucks.

Autor: Abdelnaby EA; Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Fathi M; Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Salem NY; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. Noha.Salem@cu.edu.eg., Ramadan ES; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Yehia SG; Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Emam IA; Department of Surgery, and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Salama A; Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Samir H; Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., El-Sherbiny HR; Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2024 Jul 05; Vol. 20 (1), pp. 293. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1186/s12917-024-04134-4
Abstrakt: Background: Senescence is accompanied by a progressive decrease in male reproductive performance, mainly due to oxidative stress and endothelial dysfunction. Alpha lipoic acid (ALA) is a potent antioxidant, that diffuses freely in aqueous and lipid phases, possessing anti-inflammatory and anti-apoptotic properties. This study aimed to examine the effects of supplemental dietary ALA on testicular hemodynamics (TH), circulating hormones, and semen quality in aged goats. Twelve Baladi bucks were divided into two groups (n = 6 each); the first fed a basic ration and served as a control group (CON), while the second received the basic ration supplemented with 600 mg ALA/ kg daily for consecutive eight weeks (ALA).
Results: There were improvements in testicular blood flow in the ALA group evidenced by a lower resistance index (RI) and pulsatility index (PI) concurrent with higher pampiniform-colored areas/pixel (W3-W6). There were increases in testicular volume and decreases in echogenicity (W3-W5; ALA vs. CON). Compared to the CON, ALA-bucks had higher serum concentrations of testosterone, estradiol, and nitric oxide (W3-W5). There were enhancements in semen traits (progressive motility, viability, morphology, and concentration, alanine aminotransferase enzyme) and oxidative biomarkers (catalase, total antioxidant capacity, and malondialdehyde).
Conclusions: ALA dietary supplementation (600 mg/kg diet) improved aged bucks' reproductive performance by enhancing the testicular volume, testicular hemodynamics, sex steroids, and semen quality.
(© 2024. The Author(s).)
Databáze: MEDLINE
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