Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women.

Autor: Chen HW; Department of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan.; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan., Kuo WH; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan., Lu YS; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan., Chen IC; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan.; Department of Medical Oncology, National Taiwan University Hospital, Cancer Center Branch, Taipei, Taiwan., Hu FC; Graduate Institute of Clinical Medicine and School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan.; Statistical Consulting Clinic, International-Harvard Statistical Consulting Company, Taipei, Taiwan., Wang MY; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan., Zahid M; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE, USA., Rogan EG; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE, USA., Cheng AL; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Medical Oncology, National Taiwan University Hospital, Cancer Center Branch, Taipei, Taiwan.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin CH; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. chinghlin@ntu.edu.tw.; Department of Medical Oncology, National Taiwan University Hospital, Cancer Center Branch, Taipei, Taiwan. chinghlin@ntu.edu.tw.; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. chinghlin@ntu.edu.tw.
Jazyk: angličtina
Zdroj: Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Nov; Vol. 208 (2), pp. 283-292. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1007/s10549-024-07418-3
Abstrakt: Purpose: In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The present study explored the influence of the interaction between base excision repair (BER) gene polymorphisms and estrogen-DNA adducts on breast cancer risk.
Methods: We conducted a case-control study comprising healthy volunteers and individuals with benign breast disease (control arm, n = 176) and patients with invasive carcinoma or carcinoma in situ (case arm, n = 177). Genotyping for BER-related genes, including SMUG1, OGG1, ERCC5, and APEX1, was performed. A logistic regression model, incorporating interactions between gene polymorphisms, estrogen-DNA adduct ratio, and clinical variables, was used to identify the risk factors for breast cancer.
Results: Univariate analysis indicated marginal associations between breast cancer risk and APEX1 rs1130409 T > G (P = 0.057) and APEX1 rs1760944 T > G (P = 0.065). Multivariate regression analysis revealed significant associations with increased breast cancer risk for APEX1_rs1130409 (GT/GG versus TT) combined with a natural logarithmic value of the estrogen-DNA adduct ratio (estimated OR 1.164, P = 0.023) and premenopausal status with an estrogen-DNA adduct ratio > 2.93 (estimated OR 2.433, P = 0.001).
Conclusion: APEX1_rs1130409 (GT/GG versus TT) polymorphisms, which are related to decreased BER activity, combined with an increased ratio of estrogen-DNA adducts, increase the risk of breast cancer in East Asian women.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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