Metabolic adaptations in prostate cancer.

Autor: Pujana-Vaquerizo M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Bozal-Basterra L; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160, Derio, Spain. lbozal@cicbiogune.es., Carracedo A; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160, Derio, Spain. acarracedo@cicbiogune.es.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), 28029, Madrid, Spain. acarracedo@cicbiogune.es.; Traslational Prostate Cancer Research Lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Baracaldo, Spain. acarracedo@cicbiogune.es.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. acarracedo@cicbiogune.es.; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Leioa, Spain. acarracedo@cicbiogune.es.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2024 Nov; Vol. 131 (8), pp. 1250-1262. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1038/s41416-024-02762-z
Abstrakt: Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide. Among the molecular processes that contribute to this disease, the weight of metabolism has been placed under the limelight in recent years. Tumours exhibit metabolic adaptations to comply with their biosynthetic needs. However, metabolites also play an important role in supporting cell survival in challenging environments or remodelling the tumour microenvironment, thus being recognized as a hallmark in cancer. Prostate cancer is uniquely driven by androgen receptor signalling, and this knowledge has also influenced the paths of cancer metabolism research. This review provides a comprehensive perspective on the metabolic adaptations that support prostate cancer progression beyond androgen signalling, with a particular focus on tumour cell intrinsic and extrinsic pathways.
(© 2024. The Author(s).)
Databáze: MEDLINE
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