Enhanced anticancer activity of silver doped zinc oxide magnetic nanocarrier loaded with sorafenib for hepatocellular carcinoma treatment.

Autor: Khafaga DSR; Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt. doaa.rashwan@gu.edu.eg.; Department of Basic Medical Sciences, Faculty of Medicine, Galala University, New Galala City, Suez, 43511, Egypt. doaa.rashwan@gu.edu.eg., Eid MM; Spectroscopy Department, National Research Centre, Dokki, Cairo, Egypt., Mohamed MH; Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt., Abdelmaksoud MDE; Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., Afify M; Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., El-Khawaga AM; Department of Basic Medical Sciences, Faculty of Medicine, Galala University, New Galala City, Suez, 43511, Egypt. Ahmed.Elkhawaga@gu.edu.eg., Abdelhakim HK; Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 05; Vol. 14 (1), pp. 15538. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1038/s41598-024-65235-6
Abstrakt: Drug delivery is the process or method of delivering a pharmacological product to have therapeutic effects on humans or animals. The use of nanoparticles to deliver medications to cells is driving the present surge in interest in improving human health. Green nanodrug delivery methods are based on chemical processes that are acceptable for the environment or that use natural biomaterials such as plant extracts and microorganisms. In this study, zinc oxide-superparamagnetic iron oxide-silver nanocomposite was synthesized via green synthesis method using Fusarium oxysporum fungi mycelia then loaded with sorafenib drug. The synthesized nanocomposites were characterized by UV-visibile spectroscopy, FTIR, TEM and SEM techniques. Sorafenib is a cancer treatment and is also known by its brand name, Nexavar. Sorafenib is the only systemic medication available in the world to treat hepatocellular carcinoma. Sorafenib, like many other chemotherapeutics, has side effects that restrict its effectiveness, including toxicity, nausea, mucositis, hypertension, alopecia, and hand-foot skin reaction. In our study, 40 male albino rats were given a single dose of diethyl nitrosamine (DEN) 60 mg/kg b.wt., followed by carbon tetrachloride 2 ml/kg b.wt. twice a week for one month. The aim of our study is using the zinc oxide-superparamagnetic iron oxide-silver nanocomposite that was synthesized by Fusarium oxysporum fungi mycelia as nanocarrier for enhancement the sorafenib anticancer effect.
(© 2024. The Author(s).)
Databáze: MEDLINE
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