Reconsidering lactate disallowance in pancreatic β cells.

Autor: Fu A; Diabetes Center of Excellence, University of Massachusetts, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts, Worcester, MA, USA. Electronic address: accalia.fu1@umassmed.edu.
Jazyk: angličtina
Zdroj: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2024 Dec; Vol. 35 (12), pp. 1023-1025. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1016/j.tem.2024.06.014
Abstrakt: Lactate synthesis via lactate dehydrogenase A (LDHA), traditionally considered to be a 'disallowed' function in pancreatic β cells, is redefined by Cuozzo et al. who find that lactate produced by β cells regulates fasting insulin secretion via LDHB. The metabolic sources, fates, and relevance of β cell lactate are further examined.
Competing Interests: Declaration of interests The author declares no conflicts of interests.
(Copyright © 2024 The Author. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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