Filopodia: integrating cellular functions with theoretical models.

Autor: Ruhoff VT; Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 København Ø, Denmark., Leijnse N; Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 København Ø, Denmark., Doostmohammadi A; Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 København Ø, Denmark., Bendix PM; Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 København Ø, Denmark. Electronic address: bendix@nbi.ku.dk.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1016/j.tcb.2024.05.005
Abstrakt: Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell-cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.
Competing Interests: Declaration of interests The authors declare no competing financial interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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