Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study.

Autor: Ladopoulos G; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Barda C; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece; Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Tsami K; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Vitsos A; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Didaras NA; Laboratory of Microbial Biotechnology-Molecular Bacteriology-Virology, Department of Biochemistry & Biotechnology, Faculty of Health Sciences, University of Thessaly, 41500 Larissa, Greece., Mossialos D; Laboratory of Microbial Biotechnology-Molecular Bacteriology-Virology, Department of Biochemistry & Biotechnology, Faculty of Health Sciences, University of Thessaly, 41500 Larissa, Greece., Skaltsa H; Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Sfiniadakis I; Athens Naval Hospital, Pathologoanatomic Laboratory, Athens 11521, Greece., Papaioannou GT; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece., Rallis MC; Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Greece. Electronic address: rallis@pharm.uoa.gr.
Jazyk: angličtina
Zdroj: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2024 Jul-Aug; Vol. 128, pp. 107539. Date of Electronic Publication: 2024 Jul 04.
DOI: 10.1016/j.vascn.2024.107539
Abstrakt: Acne vulgaris, a chronic inflammatory skin disease with a high prevalence worldwide, necessitates reliable preclinical models for both understanding its pathogenesis and evaluating potential anti-acne therapies. This study aims to establish a robust mouse model using intracutaneous injection of Cutibacterium acnes bacterial suspension. Three hairless mouse strains (SKH-hr1, SKH-hr2 brown, and SKH-hr2 + ApoE) were systematically compared to ascertain the stains most closely resembling acne in humans. Various assessments, including photo documentation, biophysical evaluation, blood analysis, and histopathology, were conducted. Despite all strains exhibiting acne-like lesions, SKH-hr1 mice emerged as the most suitable model, demonstrating the most satisfactory results across multiple criteria. This research underscores the significance of employing hairless mice strains as models in acne studies to enhance and facilitate the development of effective therapeutic interventions.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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