Risk of stroke development following retinal vein occlusion: A systematic review and meta-analysis.

Autor: Hashemi E; Student Research Committee, Babol University of Medical Sciences, Babol, Iran., Looha MA; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mazaherinia H; Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran., Samadaeian N; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran., Panahi NM; Student Research Committee, Babol University of Medical Sciences, Babol, Iran., Bonilla-Escobar FJ; Fundación Somos Ciencia al Servicio de la Comunidad, Fundación SCISCO/Science to Serve the Community Foundation, SCISCO Foundation, Cali, Colombia; Vision y Salud Ocular, VISOC, Ophthalmology Department, Universidad del Valle, Cali, Colombia; Ophthalmology Department, Institute for Clinical Research Education, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Arevalo JF; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: arevalojf@jhmi.edu.
Jazyk: angličtina
Zdroj: Survey of ophthalmology [Surv Ophthalmol] 2024 Nov-Dec; Vol. 69 (6), pp. 924-936. Date of Electronic Publication: 2024 Jul 03.
DOI: 10.1016/j.survophthal.2024.06.007
Abstrakt: Retinal vein occlusion (RVO) and cerebrovascular disease share common risk factors and may be independently associated; however, the strength and nature of this association remain unclear. We conducted a systematic review and meta-analysis, informed by studies from PubMed, Scopus, EMBASE, Web of Science, and Google Scholar until January 6, 2024, aimed to clarify this relationship. Eligible studies included cohorts observing stroke incidence in RVO patients for over a year. Pooled effect estimates were calculated using random-effects models, with subgroup analyses evaluating associations between RVO types (central and branch) and stroke subtypes (ischemic and hemorrhagic). Ten cohort studies with a total of 428,650 participants (86,299 RVO patients) were included. Compared to controls, RVO patients exhibited a significantly increased risk of stroke (pooled risk ratio [RR]=1.38, 95 % confidence interval (95 %CI)=1.34-1.41). Subgroup analyses indicated elevated risk for both ischemic (RR=1.37, 95 %CI=1.32-1.42) and hemorrhagic (RR=1.55, 95 %CI=1.08-2.22) strokes in RVO patients. Additionally, both central (RR=1.50, 95 %CI=1.27-1.78) and branch (RR=1.41, 95 %CI=1.32-1.50) RVO were associated with stroke risk. Sensitivity analyses confirmed consistent results across various criteria, and funnel plots indicated no publication bias. RVO significantly increases the risk of both ischemic and hemorrhagic stroke, regardless of RVO type, suggesting a strong independent association between these conditions.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J. Fernando Arevalo reports was provided by Johns Hopkins University. J. Fernando Arevalo reports a relationship with Johns Hopkins University that includes: employment. I am an associate Editor for Survey of Ophthalmology.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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