Successful Electroconvulsive Therapy in a Patient With Catatonia and Maternal Duplication 15q11-13 Syndrome.

Autor:	Homiack DR; From the Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL., Yan LE; Department of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Chicago, Chicago, IL., Petry LG; From the Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL., Lloyd JR; From the Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL., Najjar F; From the Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL., Cook EH Jr; From the Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL.
Jazyk:	angličtina
Zdroj:	The journal of ECT [J ECT] 2024 Jul 05. Date of Electronic Publication: 2024 Jul 05.
DOI:	10.1097/YCT.0000000000001054
Abstrakt:	Abstract: The 15q11-q13 chromosomal region contains genes encoding for GABA-A receptor subunits and is a known region of epigenetic modification associated with the development of neurodevelopmental disorders. The presence of at least one additional copy of the maternal 15q11-q13 results in a syndrome (maternal dup15q) characterized by intellectual disability, autism spectrum disorder, mood disorders, and epilepsy. Catatonia is a serious syndrome of behavioral and motor dysfunction, which occurs across a variety of psychiatric, neurologic, and general medical conditions, which has successfully been treated with benzodiazepines and electroconvulsive therapy. In this case report, we describe the treatment course of a patient with established maternal dup 15q with comorbid intellectual disability, autism spectrum disorder, bipolar mood disorder, and juvenile epilepsy who developed hypokinetic catatonia refractory to high-dose benzodiazepine therapy. In contrast with benzodiazepine treatment, electroconvulsive therapy resulted in rapid improvement in catatonic symptoms and return to premorbid baseline. This case suggests that electroconvulsive therapy can be safely delivered for some patients with maternal dup 15q and may be rapidly effective when benzodiazepine treatment results in inadequate symptom improvement. Competing Interests: The authors have no conflicts of interest or financial disclosures to report. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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